Inclusion and exclusion criteria
Inclusion criteria :(1) Clinical trials and retrospective studies related to the treatment of NMOSD;
(2) The participants were adult (age >= 18 years) NMOSD patients in the remission period;
(3) The drugs used in the trials included at least one of the studied drugs;
(4) The proportion of relapse-free patients and expanded disability status scale scores were reported in trials.
Exclusion criteria :
(1) The participants were not adults or patients in the acute period of NMOSD;
(2) Only the combined medication group (except the basic immunotherapy) was included in trials;
(3) Trials used a cross-over study design, and the data of the first cycle were not reported;
(4) The sample size was less than ten.
Details of
search and inclusion
Literature search : Databases : PubMed, Embase, and Cochrane Library
Search deadline : June 18, 2021.
Language was limited to English.
The terms used : “NMOSD”，satralizumab, eculizumab, inebilizumab, rituximab, azathioprine, mycophenolate mofetil, cyclophosphamide, mitoxantrone.
Literature inclusion and exclusion:A total of 1,614 literatures were identified
1,246 literatures were screened
22 literatures were assessed for eligibility
14 studies were included in the analysis.
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